Claudin 22 (CLDN22) (NM_001111319) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010]
Overview
Recombinant protein of human claudin 22 (CLDN22)
Synonyms
CLDN21
Gene ID
53842
UniProt
Q8N7P3
Accession Number mRNA
NM_001111319
Chromosomal Location
4q35.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
Field of Research
Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transmembrane
Molecular Weight
24.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CLDN22
Species
Human
Protein ID
NP_001104789
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/53842
Uniprot URL
https://www.uniprot.org/uniprot/Q8N7P3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001111319
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001104789
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