FLIP (CFLAR) (NM_001127184) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Synonyms
C-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT
Gene ID
8837
UniProt
O15519
Accession Number mRNA
NM_001127184
Chromosomal Location
2q33.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Apoptosis
Field of Research
Apoptosis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protease
Molecular Weight
25.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CFLAR
Species
Human
Protein ID
NP_001120656
Overview
Recombinant protein of human CASP8 and FADD-like apoptosis regulator (CFLAR), transcript variant 3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8837
Uniprot URL
https://www.uniprot.org/uniprot/O15519
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001127184
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001120656
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