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Aldolase (ALDOA) (NM_001127617) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]

Synonyms

ALDA; GSD12; HEL-S-87p

Gene ID

226

UniProt

P04075, V9HWN7

Accession Number mRNA

NM_001127617

Chromosomal Location

16p11.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Fructose and mannose metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Pentose phosphate pathway

Field of Research

Fructose and mannose metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Pentose phosphate pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

39.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

ALDOA

Species

Human

Protein ID

NP_001121089

Overview

Recombinant protein of human aldolase A, fructose-bisphosphate (ALDOA), transcript variant 4

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/226

Uniprot URL

https://www.uniprot.org/uniprot/P04075

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001127617

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001121089

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