Alpha 1 Antitrypsin (SERPINA1) (NM_001127704) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]
Synonyms
A1A; A1AT; AAT; alpha1AT; nNIF; PI; PI1; PRO2275
Gene ID
5265
UniProt
P01009, E9KL23
Accession Number mRNA
NM_001127704
Chromosomal Location
14q32.13
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Complement and coagulation cascades
Field of Research
Complement and coagulation cascades
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Molecular Weight
44.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SERPINA1
Species
Human
Protein ID
NP_001121176
Overview
Purified recombinant protein of Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 8
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5265
Uniprot URL
https://www.uniprot.org/uniprot/P01009
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001127704
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001121176
Curated Selection
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