LRRFIP2 (NM_001134369) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
Overview
Purified recombinant protein of Homo sapiens leucine rich repeat (in FLII) interacting protein 2 (LRRFIP2), transcript variant 3
Synonyms
HUFI-2
Gene ID
9209
UniProt
Q9Y608, A8K649
Accession Number mRNA
NM_001134369
Chromosomal Location
3p22.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
48.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
LRRFIP2
Species
Human
Protein ID
NP_001127841
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9209
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y608
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001134369
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001127841
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