Chk1 (CHEK1) (NM_001114122) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Synonyms
CHK1
Gene ID
1111
UniProt
O14757, B4DT73
Accession Number mRNA
NM_001114122
Chromosomal Location
11q24.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cell cycle, p53 signaling pathway
Field of Research
Cell cycle, p53 signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Molecular Weight
54.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CHEK1
Species
Human
Protein ID
NP_001107594
Overview
Purified recombinant protein of Homo sapiens CHK1 checkpoint homolog (S. pombe) (CHEK1), transcript variant 3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1111
Uniprot URL
https://www.uniprot.org/uniprot/O14757
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001114122
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001107594
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