YAP1 (NM_001130145) Human Recombinant Protein
Product Specifications
Background
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Synonyms
COB1; YAP; YAP2; YAP65; YKI
Gene ID
10413
UniProt
P46937, Q86T74
Accession Number mRNA
NM_001130145
Chromosomal Location
11q22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
54.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
YAP1
Species
Human
Protein ID
NP_001123617
Overview
Purified recombinant protein of Homo sapiens Yes-associated protein 1, 65kDa (YAP1), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10413
Uniprot URL
https://www.uniprot.org/uniprot/P46937
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001130145
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001123617
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