NCF2 (NM_001127651) Human Recombinant Protein
Product Specifications
Background
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
Synonyms
NCF-2; NOXA2; P67-PHOX; P67PHOX
Gene ID
4688
UniProt
P19878, A0A0S2Z457
Accession Number mRNA
NM_001127651
Chromosomal Location
1q25.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Leukocyte transendothelial migration
Field of Research
Leukocyte transendothelial migration
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
59.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NCF2
Species
Human
Protein ID
NP_001121123
Overview
Recombinant protein of human neutrophil cytosolic factor 2 (NCF2), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4688
Uniprot URL
https://www.uniprot.org/uniprot/P19878
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001127651
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001121123
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