NCF2 (NM_001127651) Human Recombinant Protein

Product Specifications

Background

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Overview

Recombinant protein of human neutrophil cytosolic factor 2 (NCF2), transcript variant 2

Synonyms

NCF-2; NOXA2; P67-PHOX; P67PHOX

Gene ID

4688

UniProt

P19878, A0A0S2Z457

Accession Number mRNA

NM_001127651

Chromosomal Location

1q25.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Leukocyte transendothelial migration

Field of Research

Leukocyte transendothelial migration

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

59.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.