CD18 (ITGB2) (NM_001127491) Human Recombinant Protein
Product Specifications
Background
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Synonyms
CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7
Gene ID
3689
UniProt
P05107, A0A494C0X7
Accession Number mRNA
NM_001127491
Chromosomal Location
21q22.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, Viral myocarditis
Field of Research
Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, Viral myocarditis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
2660030129125705
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
82.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ITGB2
Species
Human
Protein ID
NP_001120963
Overview
Purified recombinant protein of Homo sapiens integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3689
Uniprot URL
https://www.uniprot.org/uniprot/P05107
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001127491
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001120963
Curated Selection
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