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TSH Receptor (TSHR) (NM_001142626) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Overview

Purified recombinant protein of Homo sapiens thyroid stimulating hormone receptor (TSHR), transcript variant 3

Synonyms

CHNG1; hTSHR-I; LGR3

Gene ID

7253

UniProt

P16473

Accession Number mRNA

NM_001142626

Chromosomal Location

14q31.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Autoimmune thyroid disease, Neuroactive ligand-receptor interaction

Field of Research

Autoimmune thyroid disease, Neuroactive ligand-receptor interaction

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, GPCR, Transmembrane

Molecular Weight

28.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

TSHR

Species

Human

Protein ID

NP_001136098

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/7253

Uniprot URL

https://www.uniprot.org/uniprot/P16473

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001142626

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001136098

Frequently Asked Questions

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