RNF185 (NM_001135825) Human Recombinant Protein

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693) . Acts in the endoplasmic reticulum (ER) -associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036) . Protects cells from ER stress-induced apoptosis (PubMed:27485036) . Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521) . Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.