RNASEH2B (NM_001142279) Human Recombinant Protein

Product Specifications

Background

RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2) . [provided by RefSeq, Nov 2008]

Overview

Recombinant protein of human ribonuclease H2, subunit B (RNASEH2B), transcript variant 2

Synonyms

AGS2; DLEU8

Gene ID

79621

UniProt

Q5TBB1

Accession Number mRNA

NM_001142279

Chromosomal Location

13q14.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

DNA replication

Field of Research

DNA replication

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

28.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.