RNASEH2B (NM_001142279) Human Recombinant Protein
Product Specifications
Background
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2) . [provided by RefSeq, Nov 2008]
Synonyms
AGS2; DLEU8
Gene ID
79621
UniProt
Q5TBB1
Accession Number mRNA
NM_001142279
Chromosomal Location
13q14.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
DNA replication
Field of Research
DNA replication
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
28.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RNASEH2B
Species
Human
Protein ID
NP_001135751
Overview
Recombinant protein of human ribonuclease H2, subunit B (RNASEH2B), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/79621
Uniprot URL
https://www.uniprot.org/uniprot/Q5TBB1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001142279
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001135751
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