SAE1 (NM_001145713) Human Recombinant Protein
Product Specifications
Background
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]) .[supplied by OMIM, Mar 2010]
Overview
Purified recombinant protein of Homo sapiens SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 2
Synonyms
AOS1; HSPC140; SUA1; UBLE1A
Gene ID
10055
UniProt
Q9UBE0
Accession Number mRNA
NM_001145713
Chromosomal Location
19q13.32
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Ubiquitin mediated proteolysis
Field of Research
Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
32.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SAE1
Species
Human
Protein ID
NP_001139185
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10055
Uniprot URL
https://www.uniprot.org/uniprot/Q9UBE0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001145713
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001139185
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