RAB7L1 (RAB29) (NM_001135662) Human Recombinant Protein
Product Specifications
Background
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS) . May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.[UniProtKB/Swiss-Prot Function]
Synonyms
RAB7L; RAB7L1
Gene ID
8934
UniProt
O14966, Q6FGU7, B2R7I9
Accession Number mRNA
NM_001135662
Chromosomal Location
1q32.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
23 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RAB29
Species
Human
Protein ID
NP_001129134
Overview
Recombinant protein of human RAB7, member RAS oncogene family-like 1 (RAB7L1), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8934
Uniprot URL
https://www.uniprot.org/uniprot/O14966
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001135662
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001129134
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