Poliovirus Receptor (PVR) (NM_001135769) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Synonyms
CD155; HVED; Necl-5; NECL5; PVS; TAGE4
Gene ID
5817
UniProt
P15151
Accession Number mRNA
NM_001135769
Chromosomal Location
19q13.31
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cell adhesion molecules (CAMs)
Field of Research
Cell adhesion molecules (CAMs)
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
39.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PVR
Species
Human
Protein ID
NP_001129241
Overview
Purified recombinant protein of Homo sapiens poliovirus receptor (PVR), transcript variant 3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5817
Uniprot URL
https://www.uniprot.org/uniprot/P15151
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001135769
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001129241
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