Poliovirus Receptor (PVR) (NM_001135769) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Overview

Purified recombinant protein of Homo sapiens poliovirus receptor (PVR), transcript variant 3

Synonyms

CD155; HVED; Necl-5; NECL5; PVS; TAGE4

Gene ID

5817

UniProt

P15151

Accession Number mRNA

NM_001135769

Chromosomal Location

19q13.31

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cell adhesion molecules (CAMs)

Field of Research

Cell adhesion molecules (CAMs)

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

39.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.