PAFAH1B3 (NM_001145940) Human Recombinant Protein
Product Specifications
Background
This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with cognitive disability, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Synonyms
PAFAHG
Gene ID
5050
UniProt
Q15102, A0A024R0L6
Accession Number mRNA
NM_001145940
Chromosomal Location
19q13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Ether lipid metabolism, Metabolic pathways
Field of Research
Ether lipid metabolism, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
25.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PAFAH1B3
Species
Human
Protein ID
NP_001139412
Overview
Recombinant protein of human platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa (PAFAH1B3), transcript variant 3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5050
Uniprot URL
https://www.uniprot.org/uniprot/Q15102
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001145940
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001139412
Curated Selection
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