MyoGEF (PLEKHG6) (NM_001144857) Human Recombinant Protein
Selected Variant
PH33303M5
Size: 20 µg
Product Specifications
Background
Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human pleckstrin homology domain containing, family G (with RhoGef domain) member 6 (PLEKHG6), transcript variant 3
Synonyms
MyoGEF
Gene ID
55200
UniProt
Q3KR16
Accession Number mRNA
NM_001144857
Chromosomal Location
12p13.31
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
85.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PLEKHG6
Species
Human
Protein ID
NP_001138329
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/55200
Uniprot URL
https://www.uniprot.org/uniprot/Q3KR16
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001144857
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001138329
Price
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