Apoptosis inhibitor 5 (API5) (NM_001142931) Human Recombinant Protein
Product Specifications
Background
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Overview
Recombinant protein of human apoptosis inhibitor 5 (API5), transcript variant 3
Synonyms
AAC-11; AAC11
Gene ID
8539
UniProt
Q9BZZ5
Accession Number mRNA
NM_001142931
Chromosomal Location
11p12
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
50.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
API5
Species
Human
Protein ID
NP_001136403
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8539
Uniprot URL
https://www.uniprot.org/uniprot/Q9BZZ5
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001142931
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001136403
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