What is the catalog number for NEDD4 2 (NEDD4L) (NM_001144964) Human Recombinant Protein?

The catalog number for NEDD4 2 (NEDD4L) (NM_001144964) Human Recombinant Protein is PH33239M5.

What sizes are available for NEDD4 2 (NEDD4L) (NM_001144964) Human Recombinant Protein?

NEDD4 2 (NEDD4L) (NM_001144964) Human Recombinant Protein is available in the following size(s): 20 µg.

NEDD4 2 (NEDD4L) (NM_001144964) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Overview

Purified recombinant protein of Homo sapiens neural precursor cell expressed, developmentally down-regulated 4-like (NEDD4L), transcript variant b

Synonyms

HNEDD4-2; NEDD4-2; NEDD4.2; PVNH7; RSP5

Gene ID

23327

UniProt

Q96PU5, A0A024R2A4

Accession Number mRNA

NM_001144964

Chromosomal Location

18q21.31

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Endocytosis, Ubiquitin mediated proteolysis

Field of Research

Endocytosis, Ubiquitin mediated proteolysis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

98 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.