NDE1 (NM_001143979) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Synonyms
HOM-TES-87; LIS4; MHAC; NDE; NUDE; NUDE1
Gene ID
54820
UniProt
Q9NXR1, X5DR54
Accession Number mRNA
NM_001143979
Chromosomal Location
16p13.11
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
37.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NDE1
Species
Human
Protein ID
NP_001137451
Overview
Recombinant protein of human nudE nuclear distribution gene E homolog 1 (A. nidulans) (NDE1), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/54820
Uniprot URL
https://www.uniprot.org/uniprot/Q9NXR1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001143979
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001137451
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