CHFR (NM_001161344) Human Recombinant Protein
Product Specifications
Background
This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]
Synonyms
RNF116; RNF196
Gene ID
55743
UniProt
Q96EP1
Accession Number mRNA
NM_001161344
Chromosomal Location
12q24.33
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
73.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CHFR
Species
Human
Protein ID
NP_001154816
Overview
Recombinant protein of human checkpoint with forkhead and ring finger domains (CHFR), transcript variant 1.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/55743
Uniprot URL
https://www.uniprot.org/uniprot/Q96EP1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001161344
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001154816
Curated Selection
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