FHIT (NM_001166243) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a P1-P3-bis (5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]

Overview

Recombinant protein of human fragile histidine triad gene (FHIT), transcript variant 2.

Synonyms

AP3Aase; FRA3B

Gene ID

2272

UniProt

P49789, A0A024R366

Accession Number mRNA

NM_001166243

Chromosomal Location

3p14.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Non-small cell lung cancer, Purine metabolism, Small cell lung cancer

Field of Research

Non-small cell lung cancer, Purine metabolism, Small cell lung cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

16.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.