FHIT (NM_001166243) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a P1-P3-bis (5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Synonyms
AP3Aase; FRA3B
Gene ID
2272
UniProt
P49789, A0A024R366
Accession Number mRNA
NM_001166243
Chromosomal Location
3p14.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Non-small cell lung cancer, Purine metabolism, Small cell lung cancer
Field of Research
Non-small cell lung cancer, Purine metabolism, Small cell lung cancer
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
16.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
FHIT
Species
Human
Protein ID
NP_001159715
Overview
Recombinant protein of human fragile histidine triad gene (FHIT), transcript variant 2.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2272
Uniprot URL
https://www.uniprot.org/uniprot/P49789
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001166243
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001159715
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