PRKAR1B (NM_001164759) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]
Overview
Purified recombinant protein of Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, beta (PRKAR1B), transcript variant 4.
Synonyms
PRKAR1
Gene ID
5575
UniProt
P31321
Accession Number mRNA
NM_001164759
Chromosomal Location
7p22.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Apoptosis, Insulin signaling pathway
Field of Research
Apoptosis, Insulin signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
42.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PRKAR1B
Species
Human
Protein ID
NP_001158231
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5575
Uniprot URL
https://www.uniprot.org/uniprot/P31321
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001164759
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001158231
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