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PRKAR1B (NM_001164761) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]

Overview

Purified recombinant protein of Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, beta (PRKAR1B), transcript variant 1.

Synonyms

PRKAR1

Gene ID

5575

UniProt

P31321

Accession Number mRNA

NM_001164761

Chromosomal Location

7p22.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Apoptosis, Insulin signaling pathway

Field of Research

Apoptosis, Insulin signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

42.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PRKAR1B

Species

Human

Protein ID

NP_001158233

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5575

Uniprot URL

https://www.uniprot.org/uniprot/P31321

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001164761

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001158233

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