KBTBD8 (NM_032505) Human Recombinant Protein
Product Specifications
Background
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832) . The BCR (KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832) .[UniProtKB/Swiss-Prot Function]
Synonyms
TA-KRP; TAKRP
Gene ID
84541
UniProt
Q8NFY9
Accession Number mRNA
NM_032505
Chromosomal Location
3p14.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
68.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KBTBD8
Species
Human
Protein ID
NP_115894
Overview
Recombinant protein of human kelch repeat and BTB (POZ) domain containing 8 (KBTBD8) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/84541
Uniprot URL
https://www.uniprot.org/uniprot/Q8NFY9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_032505
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_115894
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