Tenascin N (TNN) (NM_022093) Human Recombinant Protein
Product Specifications
Background
Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022) . Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity) . During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity) . In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327) . Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022) .[UniProtKB/Swiss-Prot Function]
Synonyms
TN-W; TNW
Gene ID
63923
UniProt
Q9UQP3, B3KXB6
Accession Number mRNA
NM_022093
Chromosomal Location
1q25.1
Expression System
HEK293
Tag
C-HIS
Related Pathways
ECM-receptor interaction, Focal adhesion
Field of Research
ECM-receptor interaction, Focal adhesion
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, pH7.4, 10% glycerol
Function
Druggable Genome
Molecular Weight
142.3kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TNN
Species
Human
Protein ID
NP_071376
Overview
Purified recombinant protein of Human tenascin N (TNN), Glu29-End, with C-terminal His tag, secretory expressed in HEK293 cells, 50 ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/63923
Uniprot URL
https://www.uniprot.org/uniprot/Q9UQP3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022093
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_071376
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