HTRA1 Mutant (K346I) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]

Overview

Purified mutant recombinant protein of Human HtrA serine peptidase 1 (HTRA1), residues 161-369aa and mutation at (K346I)

Synonyms

ARMD7; CADASIL2; CARASIL; HtrA; L56; ORF480; PRSS11

Gene ID

5654

Accession Number mRNA

NM_002775

Chromosomal Location

10q26.13

Expression System

HEK293

Tag

Myc-DDK

Concentration

>50 ug/mL as determined by microplate Bradford method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protease, Secreted Protein

Molecular Weight

22.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.