HTRA1 Mutant (K346I) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]
Synonyms
ARMD7; CADASIL2; CARASIL; HtrA; L56; ORF480; PRSS11
Gene ID
5654
Accession Number mRNA
NM_002775
Chromosomal Location
10q26.13
Expression System
HEK293
Tag
Myc-DDK
Concentration
>50 ug/mL as determined by microplate Bradford method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protease, Secreted Protein
Molecular Weight
22.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
HTRA1
Species
Human
Protein ID
NP_002766.1
Overview
Purified mutant recombinant protein of Human HtrA serine peptidase 1 (HTRA1), residues 161-369aa and mutation at (K346I)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5654
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002775
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002766.1
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