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FGF2 (NM_002006) Human Recombinant Protein

Selected Variant

PH32516E0

Size: 100 µg

Product Specifications

Background

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human Fibroblast Growth Factor-basic (FGF2) produced in E. coli

Synonyms

BFGF; FGF-2; FGFB; HBGF-2

Gene ID

2247

UniProt

P09038

Accession Number mRNA

NM_002006

Chromosomal Location

4q28.1

Expression System

E. coli

Tag

Tag Free

Related Pathways

MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton

Field of Research

MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton

Concentration

Resuspend the protein to the desired concentration in proper buffer.

Endotoxin

< 0.1 EU per 1 µg of the protein by the LAL

Purity

>95% as determined by SDS-PAGE and Coomassie blue staining

Activity

2625320126704449294160072993720229948854

Form

Lyophilized

Buffer

Lyophilized from a sterile solution containing 10 mM Tris.Cl, pH7.0, 150mM NaCl.

Function

Druggable Genome, Secreted Protein

Molecular Weight

17.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

FGF2

Species

Human

Protein ID

NP_001997

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/2247

Uniprot URL

https://www.uniprot.org/uniprot/P09038

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002006

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001997

Price

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