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MEK7 (MAP2K7) (NM_145185) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Overview

Purified recombinant protein of Human mitogen-activated protein kinase kinase 7 (MAP2K7), full length, with C-terminal His tag, expressed in E.coli, 51ug

Synonyms

JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7; SAPKK-4; SAPKK4

Gene ID

5609

UniProt

O14733

Accession Number mRNA

NM_145185

Chromosomal Location

19p13.2

Expression System

E. coli

Tag

C-His

Related Pathways

ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway

Field of Research

ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 500mM NaCl, 10% Glycerine, pH8.0.

Function

Druggable Genome, Protein Kinase

Molecular Weight

47.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

MAP2K7

Species

Human

Protein ID

NP_660186

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5609

Uniprot URL

https://www.uniprot.org/uniprot/O14733

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_145185

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_660186

Frequently Asked Questions

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