MEK7 (MAP2K7) (NM_145185) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Overview
Purified recombinant protein of Human mitogen-activated protein kinase kinase 7 (MAP2K7), full length, with C-terminal His tag, expressed in E.coli, 51ug
Synonyms
JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7; SAPKK-4; SAPKK4
Gene ID
5609
UniProt
O14733
Accession Number mRNA
NM_145185
Chromosomal Location
19p13.2
Expression System
E. coli
Tag
C-His
Related Pathways
ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway
Field of Research
ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 500mM NaCl, 10% Glycerine, pH8.0.
Function
Druggable Genome, Protein Kinase
Molecular Weight
47.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MAP2K7
Species
Human
Protein ID
NP_660186
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5609
Uniprot URL
https://www.uniprot.org/uniprot/O14733
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_145185
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_660186
Frequently Asked Questions
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