Bcl 6 (BCL6) (NM_001706) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Synonyms
BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
Gene ID
604
UniProt
P41182
Accession Number mRNA
NM_001706
Chromosomal Location
3q27.3
Expression System
E. coli
Tag
Tag free
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
9.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
BCL6
Species
Human
Protein ID
NP_001697
Overview
Purified recombinant protein of Human B-cell CLL/lymphoma 6 (BCL6), transcript variant 1, Ser209-Pro292, tag free, expressed in E.coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/604
Uniprot URL
https://www.uniprot.org/uniprot/P41182
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001706
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001697
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