NALP4 (NLRP4) (NM_134444) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR) . This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) . [provided by RefSeq, Dec 2016]
Synonyms
CLR19.5; CT58; NALP4; PAN2; PYPAF4; RNH2
Gene ID
147945
UniProt
Q96MN2, B2RCA1
Accession Number mRNA
NM_134444
Chromosomal Location
19q13.43
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Molecular Weight
36.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NLRP4
Species
Human
Protein ID
NP_604393
Overview
Purified recombinant protein of Human NLR family, pyrin domain containing 4 (NLRP4), Met1-Tyr310, with N-terminal His tag, expressed in E.coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/147945
Uniprot URL
https://www.uniprot.org/uniprot/Q96MN2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_134444
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_604393
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