ZBTB4 (NM_020899) Human Recombinant Protein

Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS) . Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688) . Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity) .[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Human zinc finger and BTB domain containing 4 (ZBTB4), transcript variant 1, Ala788-End, with N-terminal His-PDCD1 (Pro21-Val170) tag, expressed in E.coli, 50ug

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.