HIF 2 alpha (EPAS1) (NM_001430) Human Recombinant Protein
Product Specifications
Background
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]
Overview
Purified recombinant protein of Human endothelial PAS domain protein 1 (EPAS1), Leu584-end, with N-terminal His tag, expressed in E.coli, 50ug
Synonyms
BHLHe73; ECYT4; HIF2A; HLF; MOP2; PASD2
Gene ID
2034
UniProt
Q99814, B3KW07
Accession Number mRNA
NM_001430
Chromosomal Location
2p21
Expression System
E. coli
Tag
N-His
Related Pathways
Pathways in cancer, Renal cell carcinoma
Field of Research
Pathways in cancer, Renal cell carcinoma
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Function
Druggable Genome, Transcription Factors
Molecular Weight
31.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EPAS1
Species
Human
Protein ID
NP_001421
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2034
Uniprot URL
https://www.uniprot.org/uniprot/Q99814
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001430
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001421
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