TRPC6 (NM_004621) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) . [provided by RefSeq, Mar 2009]
Overview
Purified recombinant protein of Human transient receptor potential cation channel, subfamily C, member 6 (TRPC6), Met1-Phe102, with N-terminal His-ABP tag, expressed in E.coli, 50ug
Synonyms
FSGS2; TRP6
Gene ID
7225
UniProt
Q9Y210
Accession Number mRNA
NM_004621
Chromosomal Location
11q22.1
Expression System
E. coli
Tag
N-His ABP
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Function
Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
Molecular Weight
26.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TRPC6
Species
Human
Protein ID
NP_004612
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7225
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y210
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004621
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004612
Curated Selection
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