RON (MST1R) (NM_002447) Human Recombinant Protein

Product Specifications

Background

This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

Overview

Purified recombinant protein of Human macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (MST1R), Tyr1102-End, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

CD136; CDw136; NPCA3; PTK8; RON; SEA

Gene ID

4486

UniProt

Q04912

Accession Number mRNA

NM_002447

Chromosomal Location

3p21.31

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane

Molecular Weight

34.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.