What is the catalog number for PTCH1 (NM_000264) Human Recombinant Protein?

The catalog number for PTCH1 (NM_000264) Human Recombinant Protein is PH30181E1.

What sizes are available for PTCH1 (NM_000264) Human Recombinant Protein?

PTCH1 (NM_000264) Human Recombinant Protein is available in the following size(s): 50 µg.

Is PTCH1 (NM_000264) Human Recombinant Protein in stock?

PTCH1 (NM_000264) Human Recombinant Protein is currently made to order / not held in immediate stock. Contact us for lead time.

PTCH1 (NM_000264) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017]

Overview

Purified recombinant protein of Human patched 1 (PTCH1), transcript variant 1b, Arg770-Trp1027, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

BCNS; NBCCS; PTC; PTC1; PTCH

Gene ID

5727

UniProt

Q13635

Accession Number mRNA

NM_000264

Chromosomal Location

9q22.32

Expression System

E. coli

Tag

N-His

Related Pathways

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Field of Research

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Molecular Weight

30.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.