PMS1 (NM_000534) Human Recombinant Protein
Product Specifications
Background
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]
Overview
Purified recombinant protein of Human PMS1 postmeiotic segregation increased 1 (S. cerevisiae) (PMS1), transcript variant 1, Glu323-Ser423, with N-terminal His-ABP tag, expressed in E.coli, 50ug
Synonyms
HNPCC3; hPMS1; MLH2; PMSL1
Gene ID
5378
UniProt
P54277
Accession Number mRNA
NM_000534
Chromosomal Location
2q32.2
Expression System
E. coli
Tag
N-His ABP
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea
Function
Druggable Genome, Transcription Factors
Molecular Weight
26.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PMS1
Species
Human
Protein ID
NP_000525
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5378
Uniprot URL
https://www.uniprot.org/uniprot/P54277
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000534
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000525
Frequently Asked Questions
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