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PMS1 (NM_000534) Human Recombinant Protein

Product Specifications

Background

This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human PMS1 postmeiotic segregation increased 1 (S. cerevisiae) (PMS1), transcript variant 1, Glu323-Ser423, with N-terminal His-ABP tag, expressed in E.coli, 50ug

Synonyms

HNPCC3; hPMS1; MLH2; PMSL1

Gene ID

5378

UniProt

P54277

Accession Number mRNA

NM_000534

Chromosomal Location

2q32.2

Expression System

E. coli

Tag

N-His ABP

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea

Function

Druggable Genome, Transcription Factors

Molecular Weight

26.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PMS1

Species

Human

Protein ID

NP_000525

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5378

Uniprot URL

https://www.uniprot.org/uniprot/P54277

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000534

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000525

Frequently Asked Questions

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