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DVL1 (NM_004421) Human Recombinant Protein

Selected Variant

PH30173E1

Size: 50 µg

Product Specifications

Background

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human dishevelled, dsh homolog 1 (Drosophila) (DVL1), Met1-Tyr279, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

DRS2; DVL; DVL1L1; DVL1P1

Gene ID

1855

UniProt

O14640

Accession Number mRNA

NM_004421

Chromosomal Location

1p36.33

Expression System

E. coli

Tag

N-His

Related Pathways

Basal cell carcinoma, Colorectal cancer, Melanogenesis, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway

Field of Research

Basal cell carcinoma, Colorectal cancer, Melanogenesis, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea

Function

Druggable Genome, ES Cell Differentiation/IPS

Molecular Weight

31.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

DVL1

Species

Human

Protein ID

NP_004412

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1855

Uniprot URL

https://www.uniprot.org/uniprot/O14640

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_004421

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004412

Price

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