EPX (NM_000502) Human Recombinant Protein
Product Specifications
Background
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]
Synonyms
EPO; EPP; EPX-PEN; EPXD
Gene ID
8288
UniProt
P11678
Accession Number mRNA
NM_000502
Chromosomal Location
17q22
Expression System
E. coli
Tag
N-His
Related Pathways
Asthma
Field of Research
Asthma
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea
Function
Druggable Genome
Molecular Weight
32.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EPX
Species
Human
Protein ID
NP_000493
Overview
Purified recombinant protein of Human eosinophil peroxidase (EPX), Arg140-Met422, with N-terminal His tag, expressed in E.coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8288
Uniprot URL
https://www.uniprot.org/uniprot/P11678
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000502
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000493
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