DOT1L (NM_032482) Human Recombinant Protein
Selected Variant
PH30164E1
Size: 50 µg
Product Specifications
Background
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Overview
Purified recombinant protein of Human DOT1-like, histone H3 methyltransferase (S. cerevisiae) (DOT1L), Met1-Asp434, with N-terminal His tag, expressed in E.coli, 50ug
Synonyms
DOT1; KMT4
Gene ID
84444
UniProt
Q8TEK3
Accession Number mRNA
NM_032482
Chromosomal Location
19p13.3
Expression System
E. coli
Tag
N-His
Related Pathways
Lysine degradation
Field of Research
Lysine degradation
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea
Function
Druggable Genome
Molecular Weight
49.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DOT1L
Species
Human
Protein ID
NP_115871
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/84444
Uniprot URL
https://www.uniprot.org/uniprot/Q8TEK3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_032482
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_115871
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