Laminin 5 (LAMB3) (NM_000228) Human Recombinant Protein

Product Specifications

Background

The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human laminin, beta 3 (LAMB3), transcript variant 1, Tyr146-Ser249, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

AI1A; BM600-125KDA; LAM5; LAMNB1

Gene ID

3914

UniProt

Q13751, A0A0S2Z3R6

Accession Number mRNA

NM_000228

Chromosomal Location

1q32.2

Expression System

E. coli

Tag

N-His

Related Pathways

ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer

Field of Research

ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea

Function

Druggable Genome, Secreted Protein

Molecular Weight

11.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.