NRG1 (NM_013956) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD) . [provided by RefSeq, Apr 2016]
Synonyms
ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1-IT2; SMDF
Gene ID
3084
UniProt
Q02297, Q6PK61
Accession Number mRNA
NM_013956
Chromosomal Location
8p12
Expression System
E. coli
Tag
N-His
Related Pathways
ErbB signaling pathway
Field of Research
ErbB signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea
Function
Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
Molecular Weight
24.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NRG1
Species
Human
Protein ID
NP_039250
Overview
Purified recombinant protein of Human neuregulin 1 (NRG1), transcript variant HRG-beta1, Ser20-Glu242, with N-terminal His tag, expressed in E.coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3084
Uniprot URL
https://www.uniprot.org/uniprot/Q02297
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_013956
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_039250
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