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NRG1 (NM_013956) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD) . [provided by RefSeq, Apr 2016]

Overview

Purified recombinant protein of Human neuregulin 1 (NRG1), transcript variant HRG-beta1, Ser20-Glu242, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1-IT2; SMDF

Gene ID

3084

UniProt

Q02297, Q6PK61

Accession Number mRNA

NM_013956

Chromosomal Location

8p12

Expression System

E. coli

Tag

N-His

Related Pathways

ErbB signaling pathway

Field of Research

ErbB signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea

Function

Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane

Molecular Weight

24.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

NRG1

Species

Human

Protein ID

NP_039250

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3084

Uniprot URL

https://www.uniprot.org/uniprot/Q02297

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_013956

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_039250

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