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Cytochrome P450 26B (CYP26B1) (NM_019885) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Overview

Purified recombinant protein of Human cytochrome P450, family 26, subfamily B, polypeptide 1 (CYP26B1), Pro229-End, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

CYP26A2; P450RAI-2; P450RAI2; RHFCA

Gene ID

56603

UniProt

Q9NR63

Accession Number mRNA

NM_019885

Chromosomal Location

2p13.2

Expression System

E. coli

Tag

N-His

Related Pathways

Retinol metabolism

Field of Research

Retinol metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea

Function

Druggable Genome, P450

Molecular Weight

31.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CYP26B1

Species

Human

Protein ID

NP_063938

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/56603

Uniprot URL

https://www.uniprot.org/uniprot/Q9NR63

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_019885

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_063938

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