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Tyrosinase (TYR) (NM_000372) Human Recombinant Protein

Product Specifications

Background

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]

Overview

Purified recombinant protein of Human tyrosinase (oculocutaneous albinism IA) (TYR), His19-Phe320, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3

Gene ID

7299

UniProt

P14679, L8B082

Accession Number mRNA

NM_000372

Chromosomal Location

11q14.3

Expression System

E. coli

Tag

N-His

Related Pathways

Melanogenesis, Metabolic pathways, Riboflavin metabolism, Tyrosine metabolism

Field of Research

Melanogenesis, Metabolic pathways, Riboflavin metabolism, Tyrosine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea

Function

Transmembrane

Molecular Weight

34.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

TYR

Species

Human

Protein ID

NP_000363

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/7299

Uniprot URL

https://www.uniprot.org/uniprot/P14679

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000372

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000363

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