KDM4B (NM_015015) Human Recombinant Protein

Product Specifications

Background

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Human lysine (K) -specific demethylase 4B (KDM4B), Met1-Thr348, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

JMJD2B; TDRD14B

Gene ID

23030

UniProt

O94953, A0A0C4DFL8

Accession Number mRNA

NM_015015

Chromosomal Location

19p13.3

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea

Function

Druggable Genome

Molecular Weight

40.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.