KDM4B (NM_015015) Human Recombinant Protein
Product Specifications
Background
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Human lysine (K) -specific demethylase 4B (KDM4B), Met1-Thr348, with N-terminal His tag, expressed in E.coli, 50ug
Synonyms
JMJD2B; TDRD14B
Gene ID
23030
UniProt
O94953, A0A0C4DFL8
Accession Number mRNA
NM_015015
Chromosomal Location
19p13.3
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea
Function
Druggable Genome
Molecular Weight
40.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KDM4B
Species
Human
Protein ID
NP_055830
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23030
Uniprot URL
https://www.uniprot.org/uniprot/O94953
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_015015
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055830
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