CD61 (ITGB3) (NM_000212) Human Recombinant Protein
Product Specifications
Background
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Overview
Purified recombinant protein of Human integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3), Ser536-Asp718, with N-terminal His tag, expressed in E.coli, 50ug
Synonyms
BDPLT2; BDPLT16; BDPLT24; CD61; GP3A; GPIIIa; GT; GT2
Gene ID
3690
UniProt
P05106
Accession Number mRNA
NM_000212
Chromosomal Location
17q21.32
Expression System
E. coli
Tag
N-His
Related Pathways
Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton
Field of Research
Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol
Function
Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Molecular Weight
20.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ITGB3
Species
Human
Protein ID
NP_000203
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3690
Uniprot URL
https://www.uniprot.org/uniprot/P05106
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000212
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000203
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