PGP9.5 (UCHL1) (NM_004181) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]

Overview

Purified recombinant protein of Human ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1), Met1-Cys220, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

HEL-117; HEL-S-53; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; SPG79; Uch-L1

Gene ID

7345

UniProt

P09936, V9HW74

Accession Number mRNA

NM_004181

Chromosomal Location

4p13

Expression System

E. coli

Tag

N-His

Related Pathways

Parkinson's disease

Field of Research

Parkinson's disease

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol

Function

Druggable Genome, Protease

Molecular Weight

24.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.